surmount-1 tirzepatide nejm 2022 percent weight loss 72 weeks Tirzepatide: In the SURMOUNT-1 trial, weight reduction percentages were dose-dependent: 5 mg: ~15.0% weight reduction. 10 mg: ~19.5% weight reduction. 15 mg: ~20.9% weight reduction (Jastreboff et al., 2022). https://www.nejm.org/doi/10.1056
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Weight reduction over time in tirzepatidetreated participants by early weight loss response: Post hoc analysis in SURMOUNT1 - Ard - 2025 - Diabetes, Obesity and Metabolism - Wiley Online Library
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